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New potential therapeutic strategy against a very aggressive infant bone cancer, metastatic Ewing sarcoma

Inhibition of sirtuin 1 is proposed as new treatment for metastatic

SIRT1 Inhibition
Above, untreated zebrafish fluorescently labeled proliferate and migrate to other parts of the body. Below, cells treated with the SIRT1 inhibitor lose their proliferative and migration abilities.


Suppression of Deacetylase SIRT1 Mediates Tumor-Suppressive NOTCH Response and Offers a Novel Treatment Option in Metastatic Ewing Sarcoma, doi: 10.1158/0008-5472.CAN-14-1736

IDIBELL-Bellvitge Biomedical Research Institute