Hypoxia-inducible factor-1 and its specific target gene heme oxygenase-1 are involved in acute cerebral ischemia. However, very few studies have examined in detail the changes in the hypoxia-inducible factor-1/heme oxygenase-1 signaling pathway in chronic cerebral ischemia.
Prof. Zhongxin Xu and team from China-Japan Friendship Hospital, Jilin University clarified that the hypoxia-inducible factor-1/heme oxygenase-1 signaling pathway is activated following chronic cerebral ischemia and involved in the development of cognitive impairment induced by chronic cerebral ischemia. Additionally, cilostazol treatment can decrease hypoxia-inducible factor-1α and heme oxygenase-1 expression levels, and protect against cognitive impairment induced by chronic cerebral ischemic injury through an anti-apoptotic mechanism.
These findings are published in the Neural Regeneration Research (Vol. 8, No. 19, 2013).
Article: ” Changes of hypoxia-inducible factor-1 signaling and the effect of cilostazol in chronic cerebral ischemia (PDF),” by Chen H, Wei AX, He JT, Yu M, Mang J, Xu ZX.
Neural Regen Res. 2013;8(19):1803-1813.