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Newly discovered system signals fullness, may allow viruses to enter nervous system

After each one of those big meals you ate over the holidays, the cells lining your stomach and intestines released hormones into the bloodstream to signal the brain that you were full and should stop eating.

Glia Connection
An image taken from 3-D electron microscopy reveals the structure of a neuropod — a cell in the gut that senses nutrient levels and sends signals that govern appetite, but isn’t a neuron.
Credit:Diego Bohorquez,


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Other authors on the study include ’s , , Alex Kreger, , and Fan Wang.

This work was supported by the National Institutes of Health (R01DK091946 and F32DK094704) and the Department of Veterans Affairs (I01BX002230).

Citation: “Neuroepithelial circuit formed by innervation of sensory enteroendocrine cells,” Diego V. Bohórquez, Rafiq A. Shahid, Alan Erdmann, Alex M. Kreger, Yu Wang, Nicole Calakos, Fan Wang. Journal of Clinical Investigation, January 2, 2015. DOI: 10.1172/JCI78361.

Duke University