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Not So Fast: PPAR Beta/delta Slows Insulin Secretion

Type 2 diabetes is characterized by high , , and inadequate insulin production. Insulin is secreted by pancreatic beta and the number of beta strongly influences the body’s ability to process glucose.

In this issue of the , Walter Wahli and colleagues at that PPARbeta/delta, a protein that regulates gene expression, is a critical mediator of beta islet in mice.

PPARbeta/delta-mutant mice had more beta islets and enhanced insulin secretion compared to normal mice. By examining the genes that were expressed in normal and mutant beta islets, Wahli and colleagues found that PPARbeta/delta represses genes that help beta islets secrete insulin. Further, islets lacking PPARbeta/delta released insulin more quickly than normal islets, suggesting that therapeutics targeting PPARbeta/delta in the pancreas may help stimulate insulin release in diabetic patients.

PPARβ/δ affects pancreatic β-cell mass and insulin secretion in mice
Walter Wahli
Center for Integrative Genomics, National Research Center Frontiers in Gene, Lausanne, UNK, CHE


Journal of Clinical Investigation Sept. 10, 2012