Tackling brain inflammation ameliorates Alzheimer’s disease (AD), according to a study published in The Journal of Experimental Medicine.
In mice with Alzheimer’s-like disease, removal of TREM2 (right) decreased the formation of toxic plaques (arrows) that characterize the disease.
Credit: Jay et al., 2015
TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer’s disease mouse models. Jay, T.R., et al. 2015. J. Exp. Med. doi:10.1084/jem.20142322