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Penn vet team points to new colon cancer culprit

is a heavily studied disease — and for good reason. It is one of the leading causes of cancer-related deaths worldwide, and its numbers are on the rise, from 500,000 deaths in 1990 to 700,000 in 2010.

Culprit in Colon Cancer
Msi2 (stained red) is broadly expressed in intestinal tumors that result from loss of APC. Penn researchers believe activation of Msi2 downstream of APC loss drives of stem cells and blocks stem , leading to tumor growth.


The research was supported in part by grants from the ’s and Kidney Diseases (P30DK050306) and National Cancer Institute (R01CA16865).

University of Pennsylvania