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Placebo Or Nocebo

Negative suggestion can induce symptoms of illness. Nocebo effects are the adverse events that occur during and/or as a result of negative expectations. While the positive counterpart – the – has been intensively studied in recent years, the contains few studies on nocebo phenomena. In the latest issue of Deutsches Arzteblatt International, of the and his co-authors present the underlying neurobiological mechanisms and highlight the relevance of the in everyday clinical practice (Dtsch Arztebl Int 2012; 109(26) 459).

Nocebo responses can, for instance, be brought about by unintended negative suggestion on the part of doctors or nurses, e.g., when informing the patient about the possible complications of a proposed treatment. It is also assumed that a certain proportion of the undesired effects of drugs can be attributed to nocebo effects. The mechanisms behind this phenomenon are – as with placebo effects – learning by Pavlovian conditioning and reaction to induced expectations.

What are the consequences for clinical practice? Doctors find themselves in an ethical dilemma between their obligation to tell the patient about the possible side effects of a treatment and their duty to minimize the risk of a medical intervention and thus to avoid triggering nocebo effects. As one possible strategy to solve this dilemma, Häuser et al. suggest emphasizing the tolerability of therapeutic measures. Another option, with the patient’s permission, would be to desist from discussing undesired effects during the patient briefing.


Deutsches Aerzteblatt International