During pregnancy, the health of the mother and the intrauterine environment can have dramatic and lasting effects on the child.
In this issue of the Journal of Clinical Investigation, Catherine Williamson and colleagues at Imperial College London studied the long term impact of ICP in a cohort of Finnish families. They found that as teenagers, individuals born to women with ICP had altered metabolic profiles and increased BMI.
To further understand this effect, Williams and colleagues developed a mouse model of ICP and found that offspring of ICP mothers were more susceptible to metabolic disease and diet-induced obesity.
In the companion commentary, Susan Murphy of Duke University points out that the mouse model of ICP may also be useful in identifying other factors that predispose individuals to metabolic syndrome.
TITLE: Cholestatic pregnancy programmes metabolic disease in the offspring
ACCOMPANYING COMMENTARY TITLE: Prenatal sensitization of a postnatal trigger for metabolic disease
Journal of Clinical Investigation