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Potential Neuroprotective Response Induced By Antidepressant Drug

The production of new neurons in the adult normal in response to the antidepressant, , is reported in a study published online in Neuropsychopharmacology.

The research team, which is based at the , Fujita Health University, Aichi, has previously demonstrated that exist at the surface of the adult cortex, and, moreover, that ischemia enhances the generation of new from these . These cells were accordingly named “Layer 1 Inhibitory Neuron Progenitor cells” (L1-INP). However, until now it was not known whether L1-INP-related neurogenesis could be induced in the normal adult cortex.

Tsuyoshi Miyakawa, Koji Ohira, and their colleagues employed fluoxetine, a selective serotonin reuptake inhibitor, and one of the most widely used antidepressants, to stimulate the production of new neurons from L1-INP cells. A large percentage of these newly generated neurons were inhibitory GABAergic interneurons, and their generation coincided with a reduction in apoptotic cell death following ischemia. This finding highlights the potential neuroprotective response induced by this . It also lends further support to the postulation that induction of adult neurogenesis in cortex is a relevant prevention/treatment option for neurodegenerative diseases and psychiatric disorders.


National Institute for Physiological Sciences