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Prolotherapy: nonsurgical treatment for knee osteoarthritis

A new nonsurgical approach to treating chronic pain and stiffness associated with knee osteoarthritis has demonstrated significant, lasting improvement in knee pain, function, and stiffness. This safe, two-solution treatment delivered in a series of injections into and around the knee joint is called prolotherapy, and is described in The Journal of Alternative and Complementary Medicine, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free on The Journal of Alternative and Complementary Medicine website.

David Rabago, MD, and a team of researchers from the University of Wisconsin School of Medicine and Public Health, and Meriter Health Services, Madison, WI, report substantial improvement among participants in the one-year study who received at least three of the two-solution injections. Symptom improvement ranged from 19.5-42.9% compared to baseline status.

As described in the article “Dextrose and Morrhuate Sodium Injections (Prolotherapy) for Knee Osteoarthritis: A Prospective Open-Label Trial,” reported improvement in knee pain, function, and stiffness scores exceeded the minimum for a “clinically important difference” in 50-75% of patients.

Source

Dextrose and Morrhuate Sodium Injections (Prolotherapy) for Knee Osteoarthritis: A Prospective Open-Label Trial RabagoDavid, PattersonJeffrey J., MundtMarlon, ZgierskaAleksandra, FortneyLuke, GrettieJessica, and KijowskiRichard. The Journal of Alternative and Complementary Medicine. doi:10.1089/acm.2013.0225.

Online Ahead of Print: March 17, 2014

Mary Ann Liebert, Inc./Genetic Engineering News