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Protein aggregates save cells during aging

Scientists identify new role of in neurodegeneration

Chaperone-Rich Protein Aggregates
of a long-lived nematode worm: chaperone-rich protein aggregates (green) accumulate and save the during aging.
Credit:Picture: / © MPI of Biochemistry


Walther DM*, Kasturi P*, Zheng M, Pinkert S, Vecchi G, Ciryam P, Morimoto RI, Dobson CM, Vendruscolo M, Mann M and Hartl FU: Widespread Proteome Remodeling and Aggregation in Aging C. elegans. Cell, May 7, 2015 DOI: 10.1016/j.cell.2015.03.032

Max Planck Institute of Biochemistry