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Protein Discovered That Promotes Cancers, Heart Disease; Substance Created To Block Its Effects

Strong scientific evidence suggests that high levels of a blood protein called galectin-3 may increase the risk of heart attacks, and other diseases, and help forecast the outcome of those diseases, a scientist reported at the 244th National Meeting & Exposition of the , the world’s largest .

Isaac Eliaz, M.D., who outlined the scientific case against galectin-3, said a new galectin-3 blood test approved by the can be useful in determining the risk and prognosis of numerous diseases. His presentation also included evidence that , produced from the white pulp inside orange peel and other citrus fruit, can bind and block excess galectin-3 activity.

The body cannot absorb natural citrus pectin, which passes through the GI tract undigested, Eliaz explained. Modification permits its absorption into the blood, where it blocks the negative effects of galectin-3, he added.

Eliaz said his conclusions were based on evidence from clinical trials involving close to 8,000 people.

Abstract

Dr. Isaac Eliaz discussed new research on the role of galectin-3 and modified citrus pectin () in health and disease, and as a galectin-3 inhibitor. is a polysaccharide obtained from the peel pith of citrus fruits and modified for enhanced bio-absorption and biological activity. Recent studies have shown that high concentrations of free circulating galectin-3 in the blood are seen in many different cancer patients and contribute to the metastatic spread of cancer via numerous mechanisms. High galectin-3 levels are linked to inflammation, fibrosis, progressive heart disease and cancer progression. Thus, galectin-3 can be used as a novel therapeutic target in numerous conditions. Dr. Eliaz discussed the application of a galectin-3 serum assay as a tool for risk prognosis, and explained how functions to inhibit galectin-3. Research on ’s anticancer effects, immune activation, heavy metal detoxification and synergy with specific botanicals were presented.

Source

American Chemical Society