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Psoriasis: Scratching The Surface

Psoriasis is a chronic inflammatory skin disorder that affects approximately 2% of the world’s population.

A group of inflammatory molecules known as activate an that causes , but it is unclear how the skin cells and immune cells communicate.

In a study published in the Journal of Clinical Investigation, researchers led by at the in Z├╝rich, found that mice lacking interleukin-36 (IL-36) were protected from immune-mediated skin inflammation. These results indicate that IL-36 might be a useful therapeutic target in the treatment of psoriasis.

TITLE: Psoriasiform dermatitis is driven by interleukin-36-mediated dendritic cell-keratinocyte crosstalk



Journal of Clinical Investigation