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Psoriasis: Scratching The Surface

Psoriasis is a that affects approximately 2% of the world’s population.

A group of known as interleukins activate an that causes , but it is unclear how the skin cells and immune cells communicate.

In a study published in the , researchers led by Manfred Kopf at the Swiss Federal Institute of Technology in Z├╝rich, Switzerland found that mice lacking interleukin-36 (IL-36) were protected from immune-mediated skin inflammation. These results indicate that IL-36 might be a useful therapeutic target in the treatment of psoriasis.

TITLE: is driven by interleukin-36-mediated dendritic cell-keratinocyte crosstalk



Journal of Clinical Investigation