3 days popular7 days popular1 month popular3 months popular

Rapid Response In Cases Of Smoke Poisoning

The main cause of poisoning is smoke inhalation in closed spaces during fires. Cyanides, the salts of hydrocyanic acid, inhibit cellular respiration and may lead to coma or death. The rapid administration of a is essential for . Previously, detecting cyanide in the blood took up to an hour and could only be performed in the laboratory, a lengthy process that is poorly suited for . As a result, and paramedics are forced to administer antidotes based solely on presumptive diagnoses. Now, chemists at the have succeeded in detecting blood cyanide in less than two minutes and without any laboratory equipment: UZH chemists Christine Mannel-Croise and Felix Zelder combined a cyanide color test with an extraction method to produce results quickly and reliably.

The newly developed procedure works with only a tiny drop of blood mixed in a detection vial with a pH buffer, water, and a cobalt-based chemosensor. If the blood contains cyanide, the solid phase of the vial turns purple.

Faster, easier, more versatile

“What I like most about our method is that detection is possible solely with the naked eye, and it needs only a drop of blood,” says Zelder. Quantitative measurements are also possible, thereby enabling emergency responders to determine the grade of cyanide poisoning. The correct dosage of antidote can be chosen, and detoxification can be monitored during treatment. “In principle, our method meets all the requirements for application in emergency situations,” explains Christine Männel-Croisé. Currently, Männel-Croisé and Zelder are in discussion with paramedics to test their method in cases of emergency.

Source

Further reading:

Christine Männel-Croisé and Felix Zelder. Anal. Methods, 2012, 4, 2632.

University of Zurich