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Rare form of diabetes may be treatable with muscle relaxant

A commonly prescribed may be an effective treatment for a rare but devastating form of diabetes, researchers at in St. Louis report.

induced pluripotent stem cells from the skin cells of patients with Wolfram syndrome]
As part of their study of treatment targets for , and his colleagues made induced pluripotent stem cells, like those seen above, from the skin cells of patients with Wolfram syndrome.
Credit: Urano lab


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By Jim Dryden

The research is funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) at the National Institutes of Health (), the Juvenile Diabetes Research Foundation, the , Team Alejandro, Team Ian, the Ellie White Foundation for Rare Genetic Disorders and the Jack and J.T. Snow Scientific Research Foundation. NIH grant numbers DK067493, P60 DK020579 and UL1 TR000448.

Lu S, Kanekura K, Hara T, Mahadevan J, Spears LD, Oslowski C, Martinez R, Yamazaki-Inoue M, Neilson A, Blanner P, Brown CM, Semenkovich CF, Marshall BA, Hershey T, Umezawa A, Greer PA, Urano F. A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome. PNAS Online Early Edition, Nov. 24, 2014 doi: 10.1073/pnas.1421055111

Washington University School of Medicine