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Reducing energy efficiency boosts calorie burning in muscle

Injection that makes muscles less may have potential as weight-loss therapy to treat obesity

Energy Inefficient Muscle
Scientists at the and the have developed a targeted approach that overrides muscles’ intrinsic and allows muscle to burn more energy, even during low to moderate exercise. The image shows colorized infrared images of mice after performing low-intensity exercise on a treadmill. The mouse on the right of the image was treated with a targeted vivo-morpholino injection that suppresses the KATP channel. The mouse on the left is a control.
Credit: Leonid Zingman, University of Iowa


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Zingman and Hodgson-Zingman both are members of the and the at the UI. The research team also included UI scientists Siva Rama Krishna Koganti, Zhiyong Zhu, Ekaterina Subbotina, Zhan Gao, Ana Sierra, Manuel Proenza, and Liping Yang, and Mayo Clinic researcher Alexey Alekseev.

The research was funded in part by grants from the National Institutes of Health and the Department of Veterans Affairs.

University of Iowa Health Care