Injection that makes muscles less energy efficient may have potential as weight-loss therapy to treat obesity
Scientists at the University of Iowa and the Iowa City VA Medical Center have developed a targeted approach that overrides muscles’ intrinsic energy efficiency and allows muscle to burn more energy, even during low to moderate exercise. The image shows colorized infrared images of mice after performing low-intensity exercise on a treadmill. The mouse on the right of the image was treated with a targeted vivo-morpholino injection that suppresses the KATP channel. The mouse on the left is a control.
Credit: Leonid Zingman, University of Iowa
Zingman and Hodgson-Zingman both are members of the Francois M Abboud Cardiovascular Research Center and the Fraternal Order of Eagles Diabetes Research Center at the UI. The research team also included UI scientists Siva Rama Krishna Koganti, Zhiyong Zhu, Ekaterina Subbotina, Zhan Gao, Ana Sierra, Manuel Proenza, and Liping Yang, and Mayo Clinic researcher Alexey Alekseev.
The research was funded in part by grants from the National Institutes of Health and the Department of Veterans Affairs.