3 days popular7 days popular1 month popular3 months popular

Regulating Long-Term Memory Storage

Memories are initially stored in a fragile form. A process known as memory consolidation converts these short-term memories into stable long-term memories. Memory consolidation requires changes in gene expression, which are regulated by molecules known as .

In this issue of the , researchers led by at the identified nuclear receptors that are important for in mice. In the hours after performing a memory-forming task, the mice had increased expression of the Nr4a family. Blocking the activity of these receptors prevented long term without impacting short-term memory.

Further, increased expression of Nr4a improved the effect of a memory-enhancing class of drugs known as histone-deacetylase inhibitors. This study demonstrates that the Nr4a receptor family contributes to memory formation and may serve as a therapeutic target for improving cognition.

“NR4A nuclear receptors support memory enhancement by histone deacetylase inhibitors”
Ted Abel
University of Pennsylvania, Philadelphia, PA, USA

Source

Journal of Clinical Investigation Sept. 10, 2012