Researchers of the Unit of Medicine Design and Molecular Topology (Department of Physics Chemistry) of the University of Valencia (UV) have discovered eight new active molecules against Alzheimer’s disease by a novel mechanism of action, different to the currently used medicines. The work has just been published in the PLOS One magazine.
One of the most relevant aspects of the work is that the new molecules have been designed following a mechanism which implies the inhibition of the deposit of the beta-amyloid protein, which causes the disease to originate and the creation of small fragments of protein, called oligomers, which originate in the initial stages of the disease and seem to play a determinant role in the development of the process.
The director of the team, the full university professor Jorge Galvez, specifies that molecules have been designed “following a methodology called molecular topology, the team has been working on that methodology since the Eighties”.
The laboratory testing that confirmed the activity of the new molecules was carried out by the prestigious Mount Sinai School of Medicine of New York, under the direction of Giulio M. Pasinetti, professor of neurology and director of the Centre of Excellence for complementary treatment of Alzheimer’s disease. The tests on molecules, which have shown activity both in vitro (neuronal cellular cultures) and in live (in transgenic mice), have also been performed by Japanese and North American researchers.
The group of Medicine Design and Molecular Topology of the UV has worked under the leadership of the professors Gálvez y García-Domenech in the design of many other kinds of medicines (including anticancer medicines, antihistamines, analgesics, food additives and pesticide residues, quoting some examples) being authors of more than a hundred scientific publications on these issues in international magazines, and they have taken out several national and international patents. According to Jorge Galvez, “this information demonstrates that molecular typology is a potent tool to the design of new medicines and, in general, of new active molecules in different applications, including agriculture, food, etc…”
Molecular Topology as Novel Strategy for Discovery of Drugs with A? Lowering and Anti-Aggregation Dual Activities for Alzheimer’s Disease, Jun Wang, David Land, Kenjiro Ono, Jorge Galvez, Wei Zhao, Prashant Vempati, John W. Steele, Alice Cheng, Masahito Yamada, Samara Levine, Paolo Mazzola, Giulio M. Pasinetti, PLOS ONE, DOI: 10.1371/journal.pone.0092750, published 26 March 2014.