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Researchers find source of earliest blood cells during development

Hematopoietic stem cells are now routinely used to treat patients with cancers and other disorders of the blood and immune systems, but researchers knew little about the that give rise to them during .

In a study published April 8 in Stem Cell Reports, of the Sue & , and faculty member of the Department of Molecular Biology and Biochemistry, and colleagues created novel cell assays that identified the earliest arising HSC precursors based on their ability to generate all major blood cell types (, platelets and immune cells).

This discovery of very early differentiating blood cells, Inlay said, may be very beneficial for the creation of HSC lines for clinical treatments.

“The hope is that by defining a set of markers that will allow us to make purer, cleaner populations of these precursor cells, we’ll be able to reveal the key molecular events that lead to the emergence of the first HSCs in development.

This could give us a step-by-step guide for creating these cells in a dish from pluripotent stem cell lines” added Inlay, who is an assistant professor of molecular biology & biochemistry at UC Irvine and conducted the study while a postdoctoral researcher in the Irving Weissman lab at Stanford.

The work was performed in collaboration with Thomas Serwold, now an assistant professor in the Joslin Diabetes Center at Harvard Medical School.

Source

University of California – Irvine