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Researchers Identify A New Player In Tumor Angiogenesis

Angiogenesis, or the formation of , is important for ; however, while many have been identified, little is known about the genetic regulation that promotes tumor angiogenesis.

In this issue of the Journal of Clinical Investigation, researchers led by Injune Kim at the examined the expression of SOX17, a protein that regulates in blood vessel-forming endothelial cells during development.

Using a mouse model of tumor angiogenesis, Kim and colleagues found that increased levels of SOX17 promoted tumor angiogenesis, while loss of SOX17 reduced angiogenesis and tumor growth. These results suggest that SOX17 is a potential therapeutic target to decrease angiogenesis and tumor growth.

Injune Kim
KAIST, Daejeon, KOR


Sox17 promotes tumor angiogenesis and destabilizes tumor vessels in mice

Journal of Clinical Investigation Dec. 17, 2012