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Researchers Identify Rituximab-Insensitive Cells In Patients With Refractory Thrombocytopenia Purpura

Primary immune thrombocytopenia purpura (ITP) is a bleeding disorder in which the immune system generates that destroy platelets, the cells that cause blood to clot. B cells, immune cells that produce the that recognize the platelets, develop in the spleen. ITP patients are typically treated with rituximab, a drug that deplete B cells; however, many patients stop responding to this treatment and must have their spleens removed.

In this issue of the , researchers led by and Claude-Agnès Reynaud at the in identified antibody-producing cells in the spleens of ITP patients that were not sensitive to B-cell depleting drugs. The development of these cells was promoted by and provides an explanation for why some patients develop refractory ITP.

Jean-Claude Weill
Site Necker-Enfants Malades, Paris Descartes, Paris, , FRA


B-cell depletion in immune thrombocytopenia reveals splenic long-lived plasma cells

Journal of Clinical Investigation Dec. 17, 2012