The common chemotherapy drug topotecan disrupts a gene integral for neuron communication, though the effects are reversible. The research also homes in on an underlying cause of autism.
Neurons expressing the Topoisomerase-1 gene (green).
Credit: Image by Angela Mabb, PhD
This research was funded by the National Institutes of Health, the Simons Foundation, and the Angelman Syndrome Foundation.
Topoisomerase 1 inhibition reversibly impairs synaptic function. doi: 10.1073/pnas.1413204111