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Sall4 is required for DNA repair in stem cells

A protein that helps embryonic (ESCs) retain their identity also promotes , according to a study in The Journal of Cell Biology. The findings raise the possibility that the protein, Sall4, performs a similar role in , helping them fix DNA damage to survive chemotherapy.

Sall4 Promotes DNA Repair
This is an illustrated model for the role of Sall4 in activating ATM to repair DNA damage in .
Credit: Xiong et al., 2015


Rockefeller University Press

Stemness factor Sall4 is required for DNA damage response in embryonic stem cells. Xiong, J., et al. 2015. J. Cell Biol. doi:10.1083/jcb.201408106