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Scientists discover a cause of age-related inflammation

As animals age, their immune systems gradually deteriorate, a process called immunosenescence. It is associated with systemic and , as well as with many cancers. The causes underlying this age-associated , and how it leads to diseases, are poorly understood. New work in Carnegie’s ’s lab sheds light on one protein’s involvement in suppressing immune responses in aging . It is published in Cell.

[Aging Fruit Fly Fat Bodies]
This image shows a comparison of lamin-B in the fat bodies of 10-day-old and 50-day-old fruit flies.

As animals age, their immune systems gradually deteriorate, a process called immunosenescence. It is associated with and chronic inflammatory disorders, as well as with many cancers. The causes underlying this age-associated inflammation, and how it leads to diseases, are poorly understood. New work in Carnegie’s Yixian Zheng’s lab sheds light on one protein’s involvement in suppressing immune responses in aging fruit flies. It is published in Cell.
Credit: Yixian Zheng


Source

This work was supported by a Senior Scholar Award from the Ellison Medical Foundation and the National Institute of Health.

Carnegie Institution