Touch a hot stove, and your fingers will recoil in pain because your skin carries tiny temperature sensors that detect heat and send a message to your brain saying, “Ouch! That’s hot! Let go!”
A ribbon diagram depicting the structure of the TRPV2 ion channel (blue, yellow, green) as it lies embedded in the cell membrane (orange and white). This ion channel is a temperature sensor involved in the perception of pain and heat, and therapies targeting it could one day alleviate suffering in people afflicted with chronic pain.
Credit: Mark A. Herzik Jr., Scripps Research Institute