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Scientists report on novel method for extending the life of implantable devices in situ

Blood-contacting implantable medical devices, such as stents, heart valves, ventricular assist devices, and extracorporeal support systems, as well as vascular grafts and access catheters, are used worldwide to improve patients’ lives. However, these devices are prone to failure due to the body’s responses at the blood-material interface; clots can form and inflammatory reactions can prevent the device from performing as indicated. Currently, when this occurs, the only solution is to replace the device.

Evolved Staphylococcus aureus Sortase A (eSrtA)
This is a rendering of evolved Staphylococcus aureus Sortase A (eSrtA).
Credit: Chaikof/Liu