Fluorescent imaging shows the cellular target (the red spot) for marvel molecule MCC950.
Credit: Dr Rebecca Coll.
The study was a major collaboration between six institutions, including Trinity and the Universities of Queensland, Michigan, Massachusetts and Bonn.
The work in the O’Neill laboratory was supported by Science Foundation Ireland and the European Research Council.
A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. Nature Medicine(2015)doi:10.1038/nm.3806