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Seeking Broad-Spectrum Antiviral Drugs For Common Cold And Other Infections

Scientists are reporting progress in the search for the first drugs to combat human rhinoviruses (HRVs), which cause humanity’s most common . Their study on these potential drugs for that include the common cold appears in the journal ACS Medicinal Chemistry Letters.

and colleagues note that although many HRV infections cause mild disease, they can lead to dangerous complications for millions of people with asthma and . Previous potential drugs for HRV either didn’t work or caused unacceptable side effects, leaving only one potential drug still under development in clinical trials. MacLeod’s team set out to find new antiviral candidates to meet this serious health challenge.

They describe identifying and successfully testing a group of compounds that work against , Coxsackie virus, poliovirus and enterovirus-71 – the cause of hand, foot and mouth disease. The substances work by blocking the ability of these viruses to multiply.


American Chemical Society