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“Smart bomb” engineered by researchers to attack childhood leukemia

, and their colleagues have taken the first steps towards developing a so-called “smart bomb” to attack the most common and deadly form of – called B-lineage acute lymphoblastic leukemia (ALL).

[Leukemic cells under attack by a
Leukemic cells under attack by a “smart bomb”
Credit:Image courtesy of Fatih Uckun


Uckun and his team were supported by funding from (RMI), a university-wide program kick-started by $1.2 million in funding from , dean of the . The award facilitates collaborative interactions among the USC-based regenerative medicine community.

Additional funding came from DHHS grants P30CA014089, U01-CA-151837 and R01CA-154471 from the National Cancer Institute and the Director’s New Innovator Award 1DP2OD007246-01 from National Institutes of Health. The Nautica Triathalon and its producer Michael Epstein, Couples Against Leukemia Foundation and Saban Research Institute Merit Awards also supported this work.

A rationally designed nanoparticle for RNA interference therapy in B-lineage lymphoid malignancies, EBioMedicine, available online 28 October 2014. DOI: 10.1016/j.ebiom.2014.10.013

University of Southern California – Health Sciences