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Soldiers, Athletes, Others May Benefit From Potential New Traumatic Brain Injury Treatment

A potential new treatment for traumatic brain injury (TBI), which affects thousands of soldiers, auto accident victims, athletes and others each year, has shown promise in research, scientists are reporting. TBI can occur in individuals who experience a violent blow to the head that makes the brain collide with the inside of the skull, a or exposure to a nearby explosion. The report on TBI, which currently cannot be treated and may result in or death, appears in the journal ACS Nano.

, and colleagues explain that TBI disrupts the supply of oxygen-rich blood to the brain. With the brain so oxygen-needy – accounting for only 2 percent of a person’s weight, but claiming 20 percent of the body’s – even a mild injury, such as a concussion, can have serious consequences. Reduced blood flow and resuscitation result in a build-up of free-radicals, which can kill brain cells. Despite years of far-ranging efforts, no effective treatment has emerged for TBI. That’s why the scientists tried a new approach, based on nanoparticles so small that 1000 would fit across the width of a human hair.

They describe development and successful laboratory tests of nanoparticles, called PEG-HCCs. In laboratory rats, the nanoparticles acted like antioxidants, rapidly restoring blood flow to the brain following resuscitation after TBI. “This finding is of major importance for improving patient health under clinically relevant conditions during resuscitative care, and it has direct implications for the current [TBI] war-fighter victims in the Afghanistan and Middle East theaters,” they say.

Source

The authors acknowledge funding from the Department of Defense, the National Science Foundation and the National Institutes of Health.
American Chemical Society