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Spotlighting the brain – The fluorescence of neuroscience demonstrates pathways of neurological disorders

Scientists have now described the engineering of a bright red fluorescent protein-based voltage indicator, providing pathways to understanding complex neurological disorders. Designated as FlicR1 (fluorescent indicator for voltage imaging red), these indicators enable imaging of the electrical activity of many genetically targeted neurons with high spatial and temporal resolution.

Shining a Fluorescent Light on the Brain
FlicR1 translates the electrical signals between neurons into fluorescence that can be easily measured using conventional widefield fluorescence microscopy.
Credit: Courtesy Ahmed Abdelfattah