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St. Jude researchers reveal how 2 types of immune cells can arise from 1

The fates of immune cells can be decided at the initial division of a cell. Researchers at St. Jude Children’s Research Hospital have discovered that the production of daughter cells with different roles in the immune system is driven by the lopsided distribution of the signaling protein c-Myc. Nudging c-Myc in one direction or the other could make vaccines more effective or advance immunotherapies for cancer treatment. The research appears online in the scientific journal Nature.

Distribution of c-Myc Changes Daughter T Cells' Role
The fate of daughter T cells in the immune system (lower cells in image) is decided at the first cell division and influenced by the expression level of c-Myc protein (green).
Credit: Katherine Verbist, Ph.D., St. Jude