Study in mice could lead to better treatment and prevention for humans
The effect of C. difficile on the mouse gut: Left, 24 hours after exposure: Cells of colon lining are normal Center, 30 hours after exposure: C. difficile toxin has started to damage cells, triggering inflammation & fluid buildup Right, 36 hours after exposure: Inflamed cells burst & die. C. difficile spores leave colon via diarrhea & await next host.
Credit: Young laboratory, University of Michigan
In addition to Young, Schloss and Koenigsknecht, the study’s authors are Casey Theriot, Ingrid Bergin and Cassie Schumacher. The research was funded by the National Institutes of Health grants U19AI090871, K01GM109236 and 5R01GM099514. It used the U-M Metabolomics Core, funded by NIH grant U24 DK097153. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Dynamics and Establishment of Clostridium difficile Infection in the Murine Gastrointestinal Tract. Infection and Immunity, doi: 10.1128/IAI.02768-14, March 2015 vol. 83 no. 3 934-941