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Statin use associated with reduced risk of liver cancer among those in the UK

In a nested-case control study of individuals living in the UK, a part of the world with a relatively low incidence of , statin use is associated with a decreased risk of , according to a new study published in the JNCI: Journal of the .

Previous studies have reported this association but most used data from individuals living in regions with a high liver cancer incidence rate, such as Asia. Katherine A. McGlynn, Ph.D., from the Division of Cancer Epidemiology and Genetics at the National Cancer Institute in Bethesda, MD, and colleagues analyzed data from the United Kingdom’s Clinical Practice Research Database and included 1195 liver cancer cases diagnosed between 1988 and 2011 and 4640 control patients. They found statin use was associated with a reduced risk of liver cancer overall. This relationship was strongest among current users. Furthermore, the association was apparent regardless of whether persons had diabetes or but was stronger among those who had or diabetes.

The authors conclude, “the results of the current study suggest that use of statins among persons at high risk of developing liver cancer, even in low-risk settings, may have a net cancer protective effect.”


Oxford University Press USA