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Stress May Increase Risk For Prostate Cancer

patients have increased levels of stress and anxiety; however, several recent studies have found that men who take drugs that interfere with the stress hormone have a lower incidence of prostate .

In this issue of the Journal of Clinical Investigation George Kulik and colleagues at examined the relationship between stress and cancer progression in a mouse model of prostate cancer. Kulik and colleagues found that mice that had been subjected to stress (exposed to the scent of a predator) exhibited a significantly reduced response to a drug that induces compared to their unstressed counterparts. Administration of adrenaline also blocked . Conversely, drugs that inhibited adrenaline signaling ablated the effect of stress on prostate cancer.

These findings suggest that beta-blockers, which are used for the treatment of high blood pressure and block the effects of adrenaline, could increase the efficacy of anti-cancer therapies.

In a companion commentary, Anil Sood and colleagues at discuss additional studies that will be required to move these findings from bench to bedside.

TITLE: Behavioral stress accelerates prostate cancer development in mice


ACCOMPANYING COMMENTARY TITLE: Why stress is BAD for cancer patients



Journal of Clinical Investigation Journal of Clinical Investigation