Inflammatory bowel disease (IBD), of which Crohn’s disease and ulcerative colitis are the main types, is on the increase in the United States, affecting more than 1.6 million people and explaining perhaps the increase in advertisements offering treatments and cures. Another intestinal disease is colon cancer, a leading cause of death, which is linked to diet and one’s genetic predisposition to the disease.
Balance between the two isoforms, P1 and P2, of nuclear receptor HNF4-alpha in the colonic crypt influences susceptibility to colitis and colon cancer. P1 is seen here in green. P2 is seen in red.
Credit:Poonamjot Deol, Sladek lab, UC Riverside.