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Study on dopamine neurons could instruct research into mobility and neurological disorders

team find for the first time when and why dopamine releasing cells in the are activated

  • Dopamine releasing cells in the forebrain are difficult to access in most vertebrates so the researchers examined transparent hatchling zebrafish
  • They used a technique called electrophysiology to capture electrical signals from in the forebrain whist simultaneously observing motor activity in the spinal cord
  • Research could impact on understanding of conditions such as schizophrenia and Parkinson’s disease

Scientists studying hatchling fish have made a new advance in studying a chemical in the brain that impacts on movement.

The team from the University of Leicester Department of Biology has examined transparent hatchling zebrafish to gain new insights into the working of neurons in areas of the brain that are normally difficult to access.

This zebrafish image depicts an antibody labelled spinally-projecting in the forebrain of a hatchling zebrafish.
Credit:University of Leicester


Firing Dynamics and Modulatory Actions of Supraspinal Dopaminergic Neurons during Zebrafish Locomotor Behavior, DOI: 10.1016/j.cub.2014.12.033

University of Leicester