Researchers have discovered a novel role for Mitofusin 2, and the findings may point to a new treatment for patients with diseases caused by loss of the mitochondrial protein. The study appears in The Journal of Cell Biology.
In mice, mitochondria (green) in healthy (left) and Mfn1-deficient heart muscle cells (center) are organized in a linear arrangement, but the organelles are enlarged and disorganized in Mfn2-deficient cells (right).
Credit: Mourier et al., 2015
Mitofusin 2 is required to maintain mitochondrial coenzyme Q levels Mourier, A., et al. 2015. J. Cell Biol. doi:10.1083/jcb.201411100.