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Substance from broccoli can moderate progeria defects

Children who suffer from (HGPS) age prematurely due to a defective protein in their cells.

[two cell nuclei containing human DNA]
The image shows two containing human DNA (blue). Because of the large quantity of progerin (red), the nuclei in the cells of HGPS patients (left) are deformed in comparison to nuclei with very low levels of progerin (right).
Credit: Photo: / TUM


Original publication: Gabriel D., Roedl D., and K. Djabali, Sulforaphane enhances progerin clearance in Hutchinson–Gilford progeria fibroblasts, Aging Cell, 2014. DOI: 10.1111/acel.12300

Technische Universitaet Muenchen