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Successful laboratory test of photoswitchable anti-tumor agent

Photoswitchable agents might reduce side effects of chemotherapy. So far, photodynamic therapies have been dependent on oxygen in the tissue. But hardly any oxygen exists in malignant, rapidly growing tumors. A group of researchers of KIT and the University of Kiev has now developed a photo-switchable molecule as a basis of an oxygen-independent method. Their successful laboratory tests on tumors are reported in the journal Angewandte Chemie (Applied Chemistry).

The GS-DProSw Molecule in Its Inactive Form Can Be Activated By Visible Light
The GS-DProSw molecule in its inactive form (blue) can be activated by visible light (red) and “switched off” again by UV light.
Credit: Figure: KIT