Photoswitchable agents might reduce side effects of chemotherapy. So far, photodynamic therapies have been dependent on oxygen in the tissue. But hardly any oxygen exists in malignant, rapidly growing tumors. A group of researchers of KIT and the University of Kiev has now developed a photo-switchable molecule as a basis of an oxygen-independent method. Their successful laboratory tests on tumors are reported in the journal Angewandte Chemie (Applied Chemistry).
The GS-DProSw molecule in its inactive form (blue) can be activated by visible light (red) and “switched off” again by UV light.
Credit: Figure: KIT