Researchers from the Gladstone Institutes have uncovered a new memory regulator in the brain involving adenosine receptors, which may offer a potential treatment to improve memory in Alzheimer’s disease
Astrocytes are stained in red, the A2A receptors in green, the overlap between the two shows as yellow, and the cell nuclei are in blue.
Credit:Anna Orr/Gladstone Institutes
Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory, doi:10.1038/nn.3930
Other researchers on the study include Max Wang, Kaitlyn Ho, Daniel Kim, Xin Wang, Weikun Guo, Jing Kang, Gui-Qiu Yu, Edward Hsiao, Nino Devidze, Dena Dubal, and Bruce Conklin from the Gladstone Institutes, and Anthony Adame and Eliezer Masliah from the University of California, San Diego. Funding was provided by the National Institutes of Health, the MetLife Foundation, and the National Center for Research Resources.