Atherosclerosis is widely recognized as an independent risk factor for stroke, and its occurrence is closely related to lipid metabolism.
Numerous studies using transgenic and knockout animals have shown that scavenger receptor class B type I has a protective effect against atherosclerosis.
Previous studies of scavenger receptor class B type I gene polymorphisms have focused on the exon 1 G4A polymorphism and the exon 8 C1050T polymorphism, and these polymorphic loci impact blood lipid levels and are involved in the dyslipidemia in diabetes patients.
A recent study published in the Neural Regeneration Research (Vol. 8, No. 16, 2013) entitled “Susceptibility gene for stroke or cerebral infarction in the Han population in Hunan Province of China” has verified that A allele frequency was significantly lower than that in normal controls. The serum level of high-density lipoprotein cholesterol in patients with the scavenger receptor class B type I gene G4A GA + AA genotype was significantly higher, while the serum level of low-density lipoprotein cholesterol was significantly lower than that in patients with the GG genotype, in both the atherosclerotic cerebral infarction and cerebral hemorrhage groups.
Authors believe that the G4A polymorphism of the scavenger receptor class B type I gene is a possible predisposing risk factor for atherosclerotic cerebral infarction, and that it has no association with cerebral hemorrhage in the Han population in Hunan province of China. The A allele is possibly associated with the metabolism of high-density and low-density lipoprotein cholesterol.
Article: ” Susceptibility gene for stroke or cerebral infarction in the Han population in Hunan Province of China,” by Danheng Mo1, Hongwei Xu2, Wensheng Zhou1, Qiming Yang1, Jianwen Yang1, Bo Xiao2, Qidong Yang2 (1 Department of Neurology, Hunan Provincial Mawangdui Hospital, Changsha 410016, Hunan Province, China; 2 Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China)
Mo DH, Xu HW, Zhou WS, Yang QM, Yang JW, Xiao B, Yang QD. Susceptibility gene for stroke or cerebral infarction in the Han population in Hunan Province of China. Neural Regen Res. 2013;8(16):1519-1527.