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Novel algorithm identifies DNA copy-number landscapes in African American colon cancers

Case Western Reserve scientists develop algorithm to detect DNA copy-number alterations in tumors using deep sequencing data An algorithm dubbed ENVE could be the Google for genetic aberrations — and it comes from Case Western Reserve. Remember the World Wide Web before the famed search engine? The web offered extraordinary amounts of information, but no [...]

Secondhand smoke increases stroke risk by 30 percent for nonsmokers

Nearly 800,000 people in the U.S. suffer a stroke each year. Stroke is responsible for one out of every 19 deaths in the U.S. and it is a leading cause of disability. A new study published in the American Journal of Preventive Medicine found that secondhand smoke (SHS) increases the risk of stroke by about [...]

African-Americans at lower socioeconomic levels have increased risk of heart disease

African Americans at lower socioeconomic levels, particularly women and younger adults, are at greater risk of heart disease and stroke than those in higher socioeconomic positions, according to research in the Journal of the American Heart Association. Cardiovascular disease (CVD) is the No. 1 killer of all Americans, but the burden is greater for African [...]

Rapid testing for gene variants in kidney donors may optimize transplant outcomes

Kidney transplantation outcomes from deceased African-American donors may improve through rapid testing for apolipoprotein L1 gene (APOL1) renal risk variants at the time of organ recovery, according to a new study led by researchers at Wake Forest Baptist Medical Center. Variation in the APOL1 gene is associated with up to 40 percent of all kidney [...]

Gene variants in organ donors linked to shorter survival of transplanted kidneys

Transplanted kidneys may not function long-term if they come from donors with variants in a particular gene, according to a study presented at ASN Kidney Week 2014 November 11-16 at the Pennsylvania Convention Center in Philadelphia, PA. Previous research from a single center in North Carolina found that risk variants in the apolipoprotein L1 gene [...]