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Disruption of brain-blood barrier might influence progression of Alzheimer’s

More and more data from preclinical and clinical studies strengthen the hypothesis that immune system-mediated actions contribute to and drive pathogenesis in Alzheimer’s disease. The team of Roosmarijn Vandenbroucke in the Claude Libert Group (VIB/UGent) combined their knowledge and expertise related to inflammation with the expertise in Alzheimer’s disease present in the Bart De Strooper [...]

Even mild depression puts a burden on Alzheimer’s family caregivers

Caregiving for an Alzheimer’s patient is especially burdensome for spousal and family caregivers who at the time of their near and dear one’s Alzheimer’s diagnosis suffer from depressive symptoms, according to a recent University of Eastern Finland study. The study analysed the psychological stress of family caregivers during a three-year period following the Alzheimer’s diagnosis. [...]

Identifying typical patterns in the progression towards Alzheimer’s disease

How the brain progresses from mild cognitive impairment (MCI) to Alzheimer’s-type dementia has been an enigma for the scientific community. However, a recent study by the team of Dr. Sylvie Belleville, PhD, Director of the Research Centre at the Institut universitaire de gériatrie de Montréal (Montreal Geriatric Institute) and Professor of Psychology at Université de [...]

Down syndrome research untangles therapeutic possibilities for Alzheimer’s

More than five million Americans are living with Alzheimer’s disease (AD). Of them, 400,000 also have Down syndrome. Both groups have similar looking brains with higher levels of the protein beta amyloid. In fact, patients with Down syndrome develop the abnormal protein at twice the rate. Results of a pilot study, published in the September [...]

Modulation of brain cholesterol: A new line of research in Alzheimer’s disease treatment?

We have known for some years that Alzheimer’s disease is characterised by two types of lesions, amyloid plaques and degenerated tau protein. Cholesterol plays an important role in the physiopathology of this disease. Two French research teams (Inserm/CEA/University of Lille/University of Paris-Sud ) have just shown, in a rodent model, that overexpressing an enzyme that [...]