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Antidepressants plus blood thinners cause brain cancer cells to eat themselves in mice

Scientists have been exploring the connection between tricyclic antidepressants and brain cancer since the early 2000s. There’s some evidence that the drugs can lower one’s risk for developing aggressive glioblastomas, but when given to patients after diagnosis in a small clinical trial, the antidepressants showed no effect as a treatment. In a study appearing in [...]

Target healthy cells to stop brain cancer ‘hijack’: UBC study

New UBC research into brain cancer suggests treatments should target the cells around a tumor to stop it from spreading. UBC research team Christian Naus, Wun Chey Sin and John Bechberger study glioma, the most aggressive form of adult brain cancer. Glioma has a low five-year survival rate of 30 per cent because it is [...]

Study links gene to aggressive form of brain cancer

Scientists have identified a gene mutation linked to the development of an aggressive form of brain cancer. Researchers found that errors in a gene known as TCF12 – which plays a key role in the formation of the embryonic brain are associated with more aggressive forms of a disease called anaplastic oligodendroglioma. The new research [...]

Protein FGL2 may have potential as therapy target for brain cancer

Blocking FGL2, a protein known to promote cancer, may offer a new strategy for treating brain cancer, according to a study at The University of Texas MD Anderson Cancer Center. FGL2 (fibrinogen-like protein 2) is commonly expressed in brain cancer tumors and promotes cancer development through suppressing the immune system in several ways, say scientists [...]

Study points to possible treatment for lethal pediatric brain cancer – diffuse intrinsic pontine gliomas

NIH-funded preclinical study suggests epigenetic drugs may be used to treat leading cause of pediatric brain cancer death Using brain tumor samples collected from children in the United States and Europe, an international team of scientists found that the drug panobinostat and similar gene regulating drugs may be effective at treating diffuse intrinsic pontine gliomas [...]