3 days popular7 days popular1 month popular3 months popular

Study reveals molecular genetic mechanisms driving breast cancer progression

Researchers at UT Southwestern Medical Center have uncovered how the body’s inflammatory response can alter how estrogen promotes the growth of breast cancer cells. UT Southwestern researchers identified how a combination of signaling molecules inhibits the growth of breast cancer cells, improving clinical outcomes for some subtypes of breast cancers. The combination — the steroid [...]

Even low-androgen triple-negative breast cancer responds to anti-androgen therapy

A University of Colorado Cancer Center study published in the journal Molecular Cancer Therapeutics shows that only about 1 percent of triple-negative breast cancer cells in a tumor must be “androgen-receptor-positive” to show benefit from anti-androgen therapies. There are no FDA-approved targeted therapies for triple-negative breast cancer. Clinical trials currently underway are showing promising preliminary [...]

One-two punch catches cancer cells in vulnerable state

Transition state may offer important window of time for treatment. This confocal microscopy image depicts drug-tolerant cancer cells. By hitting breast cancer cells with a targeted therapeutic immediately after chemotherapy, researchers were able to target cancer cells during a transitional stage when they were most vulnerable. Credit:Image courtesy of Aaron Goldman. __SOURCEFROM__ This work was [...]

Crucial role of breast cancer tumor suppressor revealed

A new study led by Jose Javier Bravo-Cordero, Spanish researcher at the Albert Einstein College of Medicine in New York, details how cells with low levels of the profilin 1 protein in breast tumours increase their capacity to metastasise and invade other tissues. A new study led by José Javier Bravo-Cordero, Spanish researcher at the [...]

How breast cancer cells break free to spread in the body

More than 90 percent of cancer-related deaths are caused by the spread of cancer cells from their primary tumor site to other areas of the body. A new study has identified how one important gene helps cancer cells break free from the primary tumor. Pictured are MCF-7 human breast cancer cells, stably transformed with SNAIL [...]