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Call to reimburse cutting edge breast cancer test, Australia

A breakthrough genetic test that could spare thousands of Australian women with early stage breast cancer from chemotherapy and its toxic side effects will be considered for reimbursement later this year. The multi-gene test, known as the Oncotype DX® Breast Cancer Assay, predicts a patient’s likely benefit from chemotherapy and the overall risk of breast [...]

New genetic mutation identified in melanoma cancer cells

There is strong evidence that the protein complex APC/C may function as a tumor suppressor in multiple cancers including lymphoma, colorectal and breast cancer, and now melanoma. A new study has revealed that a genetic mutation leading to repression of a specific protein, Cdh1, which interacts with APC/C, is present in melanoma cancer cells. The [...]

Stiffer breast tissue in obese women promotes tumors

Women who are obese have a higher risk and a worse prognosis for breast cancer, but the reasons why remain unclear. A Cornell study published this month in Science Translational Medicine explains how obesity changes the consistency of breast tissue in ways that are similar to tumors, thereby promoting disease. The study of mice and [...]

21-gene recurrence score and receipt of chemotherapy in patients with breast cancer

Use of the 21-gene recurrence test score was associated with lower chemotherapy use in high-risk patients and greater use of chemotherapy in low-risk patients compared with not using the test among a large group of Medicare beneficiaries, according to an article published online by JAMA Oncology. National Comprehensive Cancer Network (NCCN) guidelines recommend considering chemotherapy [...]

New ‘mutation-tracking’ blood test could predict breast cancer relapse months in advance

Scientists have developed a blood test for breast cancer able to identify which patients will suffer a relapse after treatment, months before tumours are visible on hospital scans. The test can uncover small numbers of residual cancer cells that have resisted therapy by detecting cancer DNA in the bloodstream. Researchers at The Institute of Cancer [...]