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Cancer doesn’t sleep: Myc oncogene disrupts clock and metabolism in cancer cells

Myc is a cancer-causing gene responsible for disrupting the normal 24-hour internal rhythm and metabolic pathways in cancer cells, found a team led by researchers from the Perelman School of Medicine at the University of Pennsylvania. Postdoctoral fellow Brian Altman, PhD, and doctoral student Annie Hsieh, MD, both from the lab of senior author Chi [...]

Inducing metabolic catastrophe in cancer cells

A study published in The Journal of Cell Biology describes a way to force cancer cells to destroy a key metabolic enzyme they need to survive. Cancer cells survive the stressful environment inside a tumor in part through autophagy, the controlled digestion and recycling of damaged components. However, blocking the process doesn’t kill cancer cells, [...]

Advance in photodynamic therapy offers new approach to ovarian cancer

Researchers at Oregon State University have made a significant advance in the use of photodynamic therapy to combat ovarian cancer in laboratory animals, using a combination of techniques that achieved complete cancer cell elimination with no regrowth of tumors. The findings were just published in the journal Nanomedicine: Nanotechnology, Biology and Medicine, and after further [...]

Pancreas cancer spread from multiple types of wayward cells

Penn animal study has implications for better drug design, ‘unprecedented window’ into tumor evolution Tumor cells associated with pancreatic cancer often behave like communities by working with each other to increase tumor spread and growth to different organs. Groups of these cancer cells are better than single cancer cells in driving tumor spread, according to [...]

Drug candidate kills cancer cells through overstimulation

A drug candidate that overstimulates proteins crucial for tumor growth shows promise as a new strategy to treat a wide range of cancers. The demands of rapid cell division put a strain on cancer cells, and the approach works by tipping cell stress over the edge. In the August 10 issue of Cancer Cell, American [...]