3 days popular7 days popular1 month popular3 months popular

Promising drugs turn immune system on cancer

Cancer Research UK scientists have shown that a class of experimental drug treatments already in clinical trials could also help the body’s immune system to fight cancer, according to a study published in the journal Cell. Scientists at the University of Edinburgh revealed that a protein called Focal Adhesion Kinase, or FAK – which is [...]

Antidepressants plus blood thinners cause brain cancer cells to eat themselves in mice

Scientists have been exploring the connection between tricyclic antidepressants and brain cancer since the early 2000s. There’s some evidence that the drugs can lower one’s risk for developing aggressive glioblastomas, but when given to patients after diagnosis in a small clinical trial, the antidepressants showed no effect as a treatment. In a study appearing in [...]

Digital ‘Rosetta Stone’ decrypts how mutations rewire cancer cells

Scientists have discovered how genetic cancer mutations systematically attack the networks controlling human cells, knowledge critical for the future development of personalized precision cancer treatments. Since the human genome was decoded more than a decade ago, cancer genomics studies have dominated life science worldwide and have been extremely successful at identifying mutations in individual patients [...]

Cancer doesn’t sleep: Myc oncogene disrupts clock and metabolism in cancer cells

Myc is a cancer-causing gene responsible for disrupting the normal 24-hour internal rhythm and metabolic pathways in cancer cells, found a team led by researchers from the Perelman School of Medicine at the University of Pennsylvania. Postdoctoral fellow Brian Altman, PhD, and doctoral student Annie Hsieh, MD, both from the lab of senior author Chi [...]

Switched before birth: Study shows protein creates tumor-fighting cells

Revealing a biological combat strategy worthy of a five-star general, researchers from Houston Methodist Hospital, University of Chicago and Cornell University have shown how a cell surface receptor–a specialized protein which communicates signals between a cell and the outside world–can mobilize immune cells to attack, rather than protect, malignant tumors. The researchers report their findings [...]