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Drug resistance in cancer patients linked to oxygen-bearing molecules in body, study finds

Increased levels of certain chemically reactive, oxygen-containing molecules in the body can cause patients to become resistant to cancer drugs such as chemotherapy, according to researchers at Georgia State University. The findings, published in a review article in the journal Pharmacological Research in August, suggest there is a direct link between cancer drug resistance and [...]

Research on yeast leads to evidence in key process of chromosome length – Findings could shed light on cancer, aging

Researchers at the Johns Hopkins University have found molecular evidence of how a biochemical process controls the lengths of protective chromosome tips, a potentially significant step in ultimately understanding cancer growth and aging. In a paper recently published as the cover story in the online journal eLife, biologist David C. Zappulla and graduate student Evan [...]

A step ahead of cancer cells: Important insights into resistance building

BRD4 inhibitors are among the most promising new agents in cancer therapy that are currently evaluated in clinical trials. In a study published in NATURE, a team of researchers at the Research Institute of Molecular Pathology (IMP) and Boehringer Ingelheim in Vienna reveals how leukemia cells can evade the deadly effects of BRD4 inhibition. Understanding [...]

Down but not out – inhibited Tyk2 retains anti-cancer activity

Tyrosine kinase 2 (Tyk2) is an enzyme involved in intracellular signalling and has an important role in activating the immune system. But enzymatically active Tyk2 can also promote excessive immune reactions and growth of certain cancer types. Since several years, scientists are developing substances to specifically inhibit the kinase activity of Tyk2 for the treatment [...]

Clearing a path for cancer research

EMBL-EBI researchers develop a new computational method to study biological signalling networks in healthy and cancer cells Researchers at EMBL’s European Bioinformatics Institute (EMBL-EBI) have developed a new method for studying the targets and effects of cancer drugs using data from discovery mass spectrometry (MS) experiments. The study is published in Nature Communications. Understanding the [...]